FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation.
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Subunit:
Homodimer which is arranged in a head to tail fashion.
Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity:
Ubiquitous. Prominent expression in brain, lung, and liver.
Similarity:
Contains 1 acyl carrier domain.
SWISS:
P49327
Gene ID:
2194
Database links:
Entrez Gene: 2194 Human
Entrez Gene: 14104 Mouse
Entrez Gene: 50671 Rat
Entrez Gene: 281152 Cow
Omim: 600212 Human
SwissProt: P12276 Chicken
SwissProt: Q71SP7 Cow
SwissProt: P49327 Human
SwissProt: P19096 Mouse
SwissProt: P12785 Rat
Unigene: 8951 Chicken
Unigene: 30099 Cow
Unigene: 83190 Human
Unigene: 236443 Mouse
Unigene: 9486 Rat
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