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Mouse Anti-Myoglobin antibody
Myoglobin is a small heme containing protein responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.
Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Subcellular Location:
Cytosol; Extracellular region or secreted
Similarity:
Belongs to the globin family.
SWISS:
P02144
Gene ID:
4151
Database links:
Entrez Gene: 4151 Human
Entrez Gene: 17189 Mouse
Entrez Gene: 59108 Rat
Omim: 160000 Human
SwissProt: P02144 Human
SwissProt: P04247 Mouse
SwissProt: Q9QZ76 Rat
Unigene: 517586 Human
Unigene: 404074 Mouse
Unigene: 40511 Rat
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