Mouse Anti-human CD20 antibody

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CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7.

Cat:

SLM30098M

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD20

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

Mouse IgG2a

Applications：

Flow-Cyt=not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Product Overview：

Blank control:whole blood. Primary Antibody (green line): Mouse Anti-CD20 antibody (SLM30098M) Dilution: 2ul/Test; Secondary Antibody : Goat anti-Mouse IgG-FITCDilution: 0.5ug/Test. ProtocolCells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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Unit:

Price: $376.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Function:
This protein may be involved in the regulation of B-cell activation and proliferation

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed on B-cells.

Post-translational modifications:
Phosphorylated. Might be functionally regulated by protein kinase(s).

DISEASE:
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Similarity:
Belongs to the MS4A family.

SWISS:
P11836

Gene ID:
931

Database links:

Entrez Gene: 931 Human

Omim: 112210 Human

SwissProt: P11836 Human

Unigene: 712553 Human

Picture

Blank control:whole blood.
Primary Antibody (green line): Mouse Anti-CD20 antibody (SLM30098M)
Dilution: 2ul/Test;
Secondary Antibody : Goat anti-Mouse IgG-FITC
Dilution: 0.5ug/Test.
Protocol
Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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