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Mouse Anti-NGAL/Lipocalin 2(5B3) antibody
SLM41185M(capture) is Matched Pair with SLM41186M(detection).
Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances.
Function:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Subunit:
Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.
Subcellular Location:
Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Tissue Specificity:
Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
Similarity:
Belongs to the calycin superfamily. Lipocalin family.
SWISS:
P80188
Gene ID:
3934
Database links:
Entrez Gene: 3934 Human
Entrez Gene: 16819 Mouse
Entrez Gene: 170496 Rat
Omim: 600181 Human
SwissProt: P80188 Human
SwissProt: P11672 Mouse
SwissProt: P30152 Rat
Unigene: 204238 Human
Unigene: 9537 Mouse
Unigene: 11303 Rat
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