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Mouse Anti-FGFR1OP2 antibody
FGFR1OP2 belongs to the SIKE family. The FGFR1OP2 (FGFR1 oncogene partner 2) gene was identified through its involvement in a fusion with the FGFR1 gene. FGFR1OP2 may be involved in the wound healing pathway. It is expressed in bone marrow, spleen and thymus. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T cell or B cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Function:
May be involved in wound healing pathway (By similarity).
Subcellular Location:
Cytoplasm (By similarity).
Tissue Specificity:
Expressed in bone marrow, spleen and thymus.
DISEASE:
Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Similarity:
Belongs to the SIKE family.
SWISS:
Q9NVK5
Gene ID:
26127
Database links:
Entrez Gene: 26127 Human
Entrez Gene: 67529 Mouse
Entrez Gene: 362463 Rat
Omim: 608858 Human
SwissProt: Q9NVK5 Human
SwissProt: Q9CRA9 Mouse
SwissProt: Q6TA25 Rat
Unigene: 591162 Human
Unigene: 333499 Mouse
Unigene: 68658 Rat
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