background:
The sense of taste provides animals with valuable information about the quality and nutritional value of food. A family of G protein coupled receptors are involved in taste perception and include T1R, which is involved in sweet and umami taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. T2R49 plays a role in sensing the chemical composition of the gastrointestinal content. T2R49 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLSLCbeta-2 activation and lead to the gating of TRPM5.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Similarity:
Belongs to the G-protein coupled receptor T2R family.
Database links:
UniProtKB/Swiss-Prot: P59543.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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