Rabbit Anti-IF3/FITC Conjugated antibody

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Mitocondrial Translational Initiation Factor 3; DC38; IF 3; IF 3Mt; IF-3(Mt); IF-3Mt; IF3; IF3(mt); IF3M_HUMAN; IF3Mt; mitochondrial; Mt; MTIF3; Translation initiation factor IF 3, mitochondrial precursor; Translation initiation factor IF-3.

Cat:

SL11781R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Mitocondrial Translational Initiation Factor 3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

28kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
IF3 is also known as MTIF3 (mitochondrial translational initiation factor 3), DC38, IF3(mt) or IF-3mt, and is a 278 amino acid protein that is localized to mitochondria. IF3 aids in the initiation of protein synthesis by binding the 28S ribosomal subunit, which is a protein synthesis initiation site. The 28S and 39S ribosomal structures are subunits of the 55S ribosome, whose formation is favored in the absence of IF3, because IF3 allows the subunits to remain in their free form. Altered forms of IF3 may affect IF3’s function, which could alter the availability of mitochondrial encoded proteins, leading to oxidative stress and possibly causing an increased susceptibility to Parkinson’s disease. Polymorphism of the gene encoding IF3 is thought to be associated with Parkinson’s disease.

Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

Subcellular Location:
Mitochondrion.

Similarity:
Belongs to the IF-3 family.

Database links:

Entrez Gene: 219402 Human

SwissProt: Q9H2K0 Human

Unigene: 534582 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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