background:
Tudor domain containing 3 is a 651 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one tudor domain. Expressed in lung, brain, heart, liver, placenta, kidney, pancreas and skeletal muscle, TDRD3 exists as a component of mRNA stress granules and is thought to play a role in the translation of target mRNAs, as well as in the assembly and disassembly of stress granules. Multiple isoforms of TDRD3 exist due to alternative splicing events. The gene encoding TDRD3 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
Function:
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Subunit:
Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with 'Lys-48'-linked tetra-ubiquitin, but not with monoubiquitin or 'Lys-63'-linked ubiquitin chains.
Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.
Tissue Specificity:
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Similarity:
Contains 1 Tudor domain.
Contains 1 UBA domain.
Database links:
Entrez Gene: 418823 Chicken
Entrez Gene: 452750 Chimpanzee
Entrez Gene: 537918 Cow
Entrez Gene: 81550 Human
Entrez Gene: 219249 Mouse
Entrez Gene: 306066 Rat
Entrez Gene: 431810 Xenopus laevis
Entrez Gene: 395019 Xenopus tropicalis
Omim: 614392 Human
SwissProt: Q5ZMS6 Chicken
SwissProt: Q2HJG4 Cow
SwissProt: Q9H7E2 Human
SwissProt: Q91W18 Mouse
SwissProt: Q66HC1 Rat
SwissProt: Q6NRP6 Xenopus laevis
SwissProt: Q6P1U3 Xenopus tropicalis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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