Rabbit Anti-D3R/FITC Conjugated antibody

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Apo 3; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR 3; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Apoptosis-inducing receptor A

Cat:

SL10938R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human TNFRSF25

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

43kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is expressed preferentiallyin the tissues enriched in lymphocytes, and it may play a role inregulating lymphocyte homeostasis. This receptor has been shown tostimulate NF-kappa B activity and regulate cell apoptosis. Thesignal transduction of this receptor is mediated by various deathdomain containing adaptor proteins. Knockout studies in micesuggested the role of this gene in the removal of self-reactive Tcells in the thymus. Multiple alternatively spliced transcriptvariants of this gene encoding distinct isoforms have beenreported, most of which are potentially secreted molecules. Thealternative splicing of this gene in B and T cells encounters aprogrammed change upon T-cell activation, which predominantlyproduces full-length, membrane bound isoforms, and is thought to beinvolved in controlling lymphocyte proliferation induced by T-cellactivation. [provided by RefSeq, Jul 2008].

Function:
Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis.

Subunit:
Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signalingcascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

Subcellular Location:
Isoform 1, 2, 9, 11: Cell membrane; Single-pass type I membrane protein.
Isoform 3, 4, 6, 7, 8, 10, 12:Secreted.

Tissue Specificity:
Abundantly expressed in thymocytes andlymphocytes. Detected in lymphocyte-rich tissues such as thymus,colon, intestine, and spleen. Also found in the prostate.

Post-translational modifications:
Glycosylated (Probable).

Similarity:
Contains 1 death domain.
Contains 4 TNFR-Cys repeats.

Database links:

Entrez Gene: 8718 Human

Entrez Gene: 85030 Mouse

Entrez Gene: 500592 Rat

Omim: 603366 Human

SwissProt: Q93038 Human

Unigene: 462529 Human

Unigene: 101198 Mou

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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