background:
Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. ESF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of ESF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, ESF2 forms a homodimer or a heterodimer with a related family member.
Function:
ESF2 (Early B-cell factor 2) belongs to the conserved Olf/ESF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. ESF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
Subunit:
Forms either a homodimer or a heterodimer with a relatedfamily member
Subcellular Location:
Nuclear
Similarity:
Belongs to the COE family.
Contains 1 IPT/TIG domain.
Database links:
UniProtKB/Swiss-Prot: Q9HAK2.4
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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