Rabbit Anti-PINX-1/FITC Conjugated antibody

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67-11-3 protein; FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PI

Cat:

SL9594R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PINX-1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its SLCterminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.

Function:
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

Subunit:
Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous; expressed at low levels.

Similarity:
Belongs to the PINX1 family.
Contains 1 G-patch domain.

Database links:

Entrez Gene: 54984 Human

Entrez Gene: 7480 Mouse

Entrez Gene: 305963 Rat

Omim: 606505 Human

SwissProt: Q548A5 Human

SwissProt: Q6QWG9 Human

SwissProt: Q96BK5 Human

SwissProt: Q9CZX5 Mouse

SwissProt: A4L691 Rat

Unigene: 490991 Human

Unigene: 583894 Human

Unigene: 379214 Mouse

Unigene: 15365 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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