Rabbit Anti-Calcyon/FITC Conjugated antibody

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CALCYON; Drd1ip; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5.

Cat:

SL11719R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Calcyon (3-65aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

23kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.

Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Subunit:
nteracts with CLTA.

Subcellular Location:
Cytoplasmic vesicle membrane. Cell membrane.

Tissue Specificity:
Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the NSG family.

Database links:

Entrez Gene: 50632 Human

Entrez Gene: 68566 Mouse

Entrez Gene: 192349 Rat

Omim: 604647 Human

SwissProt: Q9NYX4 Human

SwissProt: Q9DCA7 Mouse

SwissProt: P58821 Rat

Unigene: 148136 Human

Unigene: 44241 Mouse

Unigene: 27756 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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