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Rabbit Anti-SH3GL3/FITC Conjugated antibody
background:
The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex- pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein and directing 1 adrenergic receptors to the endocytic machinery.
Function:
SH3GL3 is implicated in endocytosis and may recruit other proteins to membranes with high curvature. It is found in brain and testis tissue. There are four isoforms.
Subunit:
Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with ATX2.
Subcellular Location:
Cytoplasm, early endosome membrane, peripheral membrane protein. Note: Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons.
Tissue Specificity:
Brain and testis.
Similarity:
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 6457 Human
Entrez Gene: 81921 Rat
Omim: 603362 Human
SwissProt: Q99963 Human
SwissProt: O3536 Rat
Unigene: 270055 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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