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Rabbit Anti-NPEPPS/FITC Conjugated antibody
background:
Puromycin-sensitive aminopeptidase is a 100kDa zinc metallopeptidase which degrades neuropeptides by removing amino acid residues from the amino-terminus. The protein is the most abundant aminopeptidase in the brain, however it is not exclusive to that organ. It is localized primarily in the cytoplasm, and plays a role in the metabolism of neuropeptides in nerve terminals and synaptic clefts. The human PSA gene maps to chromosome 17q 2-32.
Function:
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).
Similarity:
Belongs to the peptidase M1 family.
Database links:
Entrez Gene: 9520 Human
Entrez Gene: 19155 Mouse
Entrez Gene: 50558 Rat
Omim: 606793 Human
SwissProt: P55786 Human
SwissProt: Q11011 Mouse
Unigene: 443837 Human
Unigene: 29824 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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