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Rabbit Anti-IMP4/FITC Conjugated antibody
background:
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
The SPPLs are a group of aspartic proteases that are responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha).
Subunit:
Monomer. Homodimer. Interacts with ITM2B and TNF.
Subcellular Location:
Membrane; multi-pass membrane protein of endosomes/lysosomes.
Tissue Specificity:
Expressed predominantly in adrenal cortex and mammary gland.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the peptidase A22B family.
Contains 1 PA (protease associated) domain.
Database links:
Entrez Gene: 56928 Human
SwissProt: Q8TCT7 Human
Unigene: 330742 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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