background:
The intronless STH gene lies between exons 9 and 10 of the tau gene, which is implicated in a number of neurodegenerative disorders. It encodes a 128 residue protein with no clear homologs, and mimics the expresison patterns of tau. Though a polymorphism (Q7R) appears significant, data does not clearly show thus far whether or not this phenotype provides a useful marker for Alzheimer’s or other forms of neurodegenerative disease.
Function:
Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions.
Database links:
Entrez Gene: 246744 Human
Omim: 607067 Human
SwissProt: Q8IWL8 Human
Unigene: 661831 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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