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Rabbit Anti-PADI2/FITC Conjugated antibody
background:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the deimination of arginine residues of proteins.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the protein arginine deiminase family.
Database links:
Entrez Gene: 1148 Human
Entrez Gene: 18600 Mouse
Entrez Gene: 29511 Rat
Omim: 607935 Human
SwissProt: Q96DA7 Human
SwissProt: Q9Y2J8 Human
SwissProt: Q08642 Mouse
SwissProt: Q75WD0 Mouse
SwissProt: P20717 Rat
Unigene: 33455 Human
Unigene: 2296 Mouse
Unigene: 469220 Mouse
Unigene: 98523 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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