Rabbit Anti-Aggrecan/FITC Conjugated antibody

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Brevican; Aggrecan; BCAN; BEHAB; Brain enriched hyaluronan binding protein; Brevican core protein; Brevican core protein isoform 1; Brevican core protein isoform 2; Brevican proteoglycan; Chondroitin sulfate proteoglycan 7; Chondroitin sulfate proteoglyca

Cat:

SL11655R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Brevican/aggrecan (601-700aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

99kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

Function:
Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique SLCterminal epitope EAMESE.

Subunit:
Interacts with TNR

Subcellular Location:
Isoform 1 is secreted, extracellular space, extracellular matrix; Isoform 2 is found on the membrane; Lipid-anchor, GPI-anchor.

Post-translational modifications:
Contains mostly chondroitin sulfate. O-glycosylated with a core 1 or possibly core 8 glycan.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 SLCtype lectin domain.
Contains 1 EGF-like domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 176 Human

Entrez Gene: 11595 Mouse

Entrez Gene: 58968 Rat

Entrez Gene: 403828 Dog

Omim: 155760 Human

SwissProt: Q28343 Dog

SwissProt: P16112 Human

SwissProt: Q61282 Mouse

SwissProt: P07897 Rat

Unigene: 2159 Human

Unigene: 358571 Mouse

Unigene: 54503 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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