background:
Basic helix-loop-helix (bHLH) proteins are a group of transcription factors that influence the regulation of neurogenesis, cardiogenesis, myogenesis, differentiation and cell proliferation. p60TRP (p60-transcription-regulator-protein), also known as SHLHb9 (basic helix-loop-helix domain containing, class B, 9) or p60-like protein, is a 547 amino acid cytoplasmic and nuclear protein that belongs to the GPRASP family. A few members of the GRASP family are considered G protein-coupled receptors that play a role in many different stimulus-response pathways. Highly expressed in brain, p60TRP may be involved in the control of cellular aging and survival. In colon cancer cells, p60TRP is down regulated due to CpG hypermethylation of its promoter, and patients suffering from Alzheimer disease have low levels of p60TRP. p60TRP binds to karyopherin ∫3, also known as Ran BP-5, and protein-phosphatase-2A (PP2A), and is encoded by a gene located on human chromosome Xq22.1.
Function:
SHLHB9, or basic helix loop helix domain containing, class B 9, interacts with the Ran-binding-protein-5 (RanBP5) and the protein-phosphatase-2A (PP2A). It can also affect NNT1 and p48ZnF signaling and is down-regulated in the brain of AD subjects. Thus SHLHB9 may have a possible pivotal role in the control of cellular aging and survival. Hypermethylation of the SHLHB9 gene occurs in premalignant lesions and accumulates during tumorigenesis.
Subcellular Location:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level.
Tissue Specificity:
Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.
Similarity:
Belongs to the GPRASP family.
Database links:
UniProtKB/Swiss-Prot: Q6PI77.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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