background:
Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Function:
May modulate the internalization of beta-amyloid precursor protein.
Subunit:
Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.
Tissue Specificity:
Expressed in various tissues.
Similarity:
Contains 2 PID domains.
Contains 1 WW domain.
Database links:
Entrez Gene: 10307 Human
Entrez Gene: 225372 Mouse
Entrez Gene: 117026 Rat
Omim: 602711 Human
SwissProt: O95704 Human
SwissProt: Q8R1C9 Mouse
SwissProt: O35827 Rat
Unigene: 529449 Human
Unigene: 89673 Mouse
Unigene: 30067 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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