Rabbit Anti-REG4/FITC Conjugated antibody

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Gastrointestinal secretory protein; GISP; REG IV; REG like protein; Regenerating gene type IV; Regenerating islet derived family member 4; Regenerating islet derived protein 4 precursor; REGIV; RELP; REG4_HUMAN.

Cat:

SL10036R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human REG4/RELP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

18kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Reg IV is part of the regenerating gene family within the SLCtype lectin superfamily. This family is involved in liver, pancreatic, gastric and intestinal cell proliferation and differentiation. Reg IV is a 158-amino acid secretory protein implicated in cell regeneration and/or survival with a definite growth stimulating effect on pancreatic beta cells. It is highly expressed in colorectal, gastric, prostate and other types of cancer. Reg ISLVpositive tumor cells display different phenotypes including mucus-secreting, enterocyte-like, and undifferentiated.

Function:
May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.

Similarity:
Contains 1 SLCtype lectin domain.

Database links:

Entrez Gene: 83998 Human

Omim: 609846 Human

SwissProt: Q9BYZ8 Human

Unigene: 660883 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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