Rabbit Anti-Nectin 4/FITC Conjugated antibody

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Ig superfamily receptor LNIR; Nectin 4; poliovirus receptor-related 4; PRR4; poliovirus receptor related 4; DKFZp686K05193; EDSS1; Nectin-4; poliovirus receptor-related 4; Processed poliovirus receptor-related protein 4; pvrl4; PVRL4_HUMAN.

Cat:

SL10029R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Nectin 4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

53kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like SLVtype domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Function:
Self-associates. Interacts via its Ig-like SLVtype domain with PVRL1/nectin-1 Ig-like SLVtype domain. Interacts via its SLCterminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, adherens junction. Processed poliovirus receptor-related protein 4: Secreted.

Tissue Specificity:
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

Database links:

Entrez Gene: 81607 Human

Entrez Gene: 71740 Mouse

Entrez Gene: 498281 Rat

Omim: 609607 Human

SwissProt: Q5E9Z9 Cow

SwissProt: Q96NY8 Human

SwissProt: Q8R007 Mouse

Unigene: 492490 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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