background:
Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2
Subcellular Location:
Membrane; Multi pass membrane protein.
Tissue Specificity:
Highly expressed throughout the brain. Detected at low levels in heart.
Similarity:
Belongs to the potassium channel HCN family.
Contains 1 cyclic nucleotide-binding domain.
Database links:
Entrez Gene: 10021 Human
Entrez Gene: 610 Human
Entrez Gene: 15166 Mouse
Entrez Gene: 330953 Mouse
Entrez Gene: 114244 Rat
Entrez Gene: 59266 Rat
Omim: 602781 Human
Omim: 605206 Human
SwissProt: Q9UL51 Human
SwissProt: Q9Y3Q4 Human
SwissProt: O70507 Mouse
SwissProt: O88703 Mouse
SwissProt: Q9JKA7 Rat
SwissProt: Q9JKA9 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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