background:
Polycystin-1L3 is a 1,732 amino acid multi-pass membrane protein that contains one PLAT domain, one GPS domain and one SLCtype lectin domain. Expressed at high levels in placenta and present at lower levels in lung and heart, Polycystin-1L3 is thought to function as an ion-channel regulator that may interact with Polycystin-L and play a role in heteromeric taste channels. The gene encoding Polycystin-1L3 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
PKD1L3 belongs to the polycystin family. It may function as an ion-channel regulator and may function with PKD2L1 as heteromeric taste channels.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in placenta, weakly in heart and lung.
Similarity:
Belongs to the polycystin family.
Contains 1 SLCtype lectin domain.
Contains 1 GPS domain.
Contains 1 PLAT domain.
Database links:
Entrez Gene: 342372 Human
Omim: 607895 Human
SwissProt: Q7Z443 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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