background:
Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.
Function:
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Subunit:
Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Similarity:
Belongs to the nicastrin family.
Database links:
Entrez Gene: 56926 Human
Entrez Gene: 103425 Mouse
Entrez Gene: 314648 Rat
Omim: 609156 Human
SwissProt: Q969V3 Human
SwissProt: Q8VCM8 Mouse
SwissProt: Q5XIA1 Rat
Unigene: 657032 Human
Unigene: 302791 Mouse
Unigene: 4202 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与γ-分泌酶的组装和成熟密切相关,其构象及表达变化对γ-分泌酶活性和阿尔茨海默病(Alzheimer's disease,AD)中β淀粉样蛋白(amyloid proteinβ,Aβ)的产生及降解也起重要调节作用。
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