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Rabbit Anti-RND2/Rho7/FITC Conjugated antibody
background:
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
Function:
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily.
Subunit:
Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.
Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side (Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.
Tissue Specificity:
Highly expressed in testis.
Similarity:
Belongs to the small GTPase superfamily. Rho family.
Database links:
Entrez Gene: 8153 Human
Entrez Gene: 11858 Mouse
Entrez Gene: 303553 Rat
Omim: 601555 Human
SwissProt: P52198 Human
SwissProt: Q9QYM5 Mouse
Unigene: 603111 Human
Unigene: 378883 Mouse
Unigene: 22162 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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