background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in brain.
Similarity:
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.
Database links:
Entrez Gene: 9771 Human
Entrez Gene: 217944 Mouse
Entrez Gene: 362799 Rat
Omim: 609527 Human
SwissProt: Q92565 Human
SwissProt: Q8C0Q9 Mouse
SwissProt: P83900 Rat
Unigene: 174768 Human
Unigene: 713217 Human
Unigene: 227642 Mouse
Unigene: 22381 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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