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Rabbit Anti-RAPGEF2/FITC Conjugated antibody
background:
SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Function:
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.
Subunit:
Interacts with MAGI2.
Subcellular Location:
Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane
Tissue Specificity:
Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta.
Post-translational modifications:
Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 cyclic nucleotide-binding domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 PDZ (DHR) domain.
Contains 1 Ras-associating domain.
Contains 1 Ras-GEF domain.
Database links:
Entrez Gene: 9693 Human
Omim: 609530 Human
SwissProt: Q9Y4G8 Human
Unigene: 723853 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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