background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC12 (zinc finger, DHHC domain containing 12), also known as ZNF400, is a 267 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteine-conjugated protein to a S-palmitoyl protein and free CoA. Three isoforms exist due to alternative splicing events. The gene encoding ZDHHC12 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Chromosome 9 is considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype.
Subcellular Location:
Membrane; Multi-pass membrane protein
Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHSLCtype zinc finger.
Database links:
Entrez Gene: 505354 Cow
Entrez Gene: 608478 Dog
Entrez Gene: 100066906 Horse
Entrez Gene: 84885 Human
Entrez Gene: 100519816 Pig
Entrez Gene: 366014 Rat
SwissProt: Q96GR4 Human
SwissProt: Q6DGF5 Rat
Unigene: 133122 Human
Unigene: 95138 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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