background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.
Function:
May play a role in the development and maintenance of the vertebrate nervous system.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein
Tissue Specificity:
Expressed in neuronal tissues.
Similarity:
Belongs to the LRRTM family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Database links:
Entrez Gene: 347731 Human
Entrez Gene: 216028 Mouse
Entrez Gene: 29876 Rat
Omim: 610869 Human
SwissProt: Q86VH5 Human
SwissProt: Q8BZ81 Mouse
Unigene: 652155 Human
Unigene: 431318 Mouse
Unigene: 214114 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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