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Rabbit Anti-GNAT2/FITC Conjugated antibody
background:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Subunit:
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Tissue Specificity:
Retinal rod outer segment.
DISEASE:
Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4) [MIM:139340]. Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination.
Similarity:
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Database links:
Entrez Gene: 2780 Human
Entrez Gene: 14686 Mouse
Entrez Gene: 365901 Rat
Omim: 139340 Human
SwissProt: P19087 Human
SwissProt: P50149 Mouse
Unigene: 36973 Human
Unigene: 439652 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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