background:
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].
Function:
EN1 and EN2 encode homeodomain containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. EN2 may play a role in susceptibility to autism spectrum disorders.
Subcellular Location:
Nuclear.
DISEASE:
Note=Genetic variations in EN2 may be associated with susceptibility to autism.
Similarity:
Belongs to the engrailed homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 2020 Human
Entrez Gene: 13799 Mouse
Entrez Gene: EN2 Rat
Omim: 131310 Human
SwissProt: Q05917 Chicken
SwissProt: P19622 Human
SwissProt: P09066 Mouse
Unigene: 134989 Human
Unigene: 4298 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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