Rabbit Anti-Dispatched/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Dispatched/FITC Conjugated antibody

DISP1; DISP 1; disp1; DISP1_HUMAN; DISPA; Dispatched A; Dispatched homolog 1; DKFZP434I0428; FLJ43740; MGC104180; MGC13130; MGC16796; Protein dispatched homolog 1.

Cat:

SL11549R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Dispatched (301-400aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

171kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

Function:
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal

Subcellular Location:
Membrane; Multi-pass membrane protein

Similarity:
Belongs to the dispatched family.
Contains 1 SSD (sterol-sensing) domain.

Database links:

Entrez Gene: 84976 Human

Entrez Gene: 68897 Mouse

Omim: 607502 Human

SwissProt: Q96F81 Human

SwissProt: Q3TDN0 Mouse

Unigene: 528817 Human

Unigene: 358721 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall