background:
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Subunit:
Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1.
Post-translational modifications:
Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.
Similarity:
Contains 1 PID domain.
Database links:
Entrez Gene: 1600 Human
Entrez Gene: 13131 Mouse
Entrez Gene: 266729 Rat
Entrez Gene: 374083 Chicken
Omim: 603448 Human
SwissProt: O75553 Human
SwissProt: P97318 Mouse
SwissProt: Q8CJH2 Rat
Unigene: 477370 Human
Unigene: 289682 Mouse
Unigene: 206534 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
