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Rabbit Anti-Calcipressin 1/DSCR 1/FITC Conjugated antibody
background:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Subunit:
Interacts with RAF1.
Tissue Specificity:
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Similarity:
Belongs to the RCAN family.
Database links:
Entrez Gene: 1827 Human
Entrez Gene: 54720 Mouse
Entrez Gene: 266766 Rat
Omim: 602917 Human
SwissProt: P53805 Human
SwissProt: Q9JHG6 Mouse
SwissProt: Q6IN33 Rat
Unigene: 282326 Human
Unigene: 265744 Mouse
Unigene: 12942 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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