background:
Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
Function:
May be involved in synaptic functions in the CNS.
Subunit:
Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4
Subcellular Location:
Secreted. Cell junction, synapse (By similarity). Note=Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2
Similarity:
Contains 1 C1q domain.
Database links:
Entrez Gene: 643866 Human
Entrez Gene: 56410 Mouse
Omim: 612978 Human
SwissProt: Q6UW01 Human
SwissProt: Q9JHG0 Mouse
Unigene: 207603 Human
Unigene: 97163 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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