Rabbit Anti-PCSK2/Proprotein Convertase 2/FITC Conjugated antibody

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KEX2 like endoprotease 2; KEX2-like endoprotease 2; NEC 2; NEC2; NEC2_HUMAN; Neuroendocrine convertase 2; PC2; PCSK2; Prohormone convertase 2; Proprotein convertase 2; Proprotein convertase subtilisin/kexin type 2; SPC2.

Cat:

SL11533R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Chicken,Dog,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Proprotein Convertase 2 (201-300aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

58kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

Function:
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

Similarity:
Belongs to the peptidase S8 family. Furin subfamily.

Database links:

Entrez Gene: 5126 Human

Entrez Gene: 18549 Mouse

Omim: 162151 Human

SwissProt: P16519 Human

SwissProt: P21661 Mouse

Unigene: 315186 Human

Unigene: 294493 Mouse

Unigene: 447466 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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