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Rabbit Anti-PTPRN/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Function:
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Subunit:
Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage.
Subcellular Location:
Membrane. Neuroendocrine secretory granules.
Tissue Specificity:
Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.
Post-translational modifications:
Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Database links:
Entrez Gene: 5798 Human
Entrez Gene: 19275 Mouse
Entrez Gene: 116660 Rat
Entrez Gene: 286810 Cow
Omim: 601773 Human
SwissProt: P56722 Cow
SwissProt: Q16849 Human
SwissProt: Q60673 Mouse
SwissProt: Q63259 Rat
Unigene: 89655 Human
Unigene: 2902 Mouse
Unigene: 11097 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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