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Home > Product > Antibody > Rabbit Anti-LAR/FITC Conjugated antibody
LAR; LAR protein; LARFN5C; PTPRF; LARS; LCA homolog; Leukocyte antigen related (LAR) PTP receptor; Leukocyte antigen related; Leukocyte antigen related PTP receptor; Leukocyte antigen related tyrosine phosphatase; Leukocyte common antigen related; Protein
Cat:
SL11530R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human PTPRF (30-100aa)
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
210kDa
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Product PDFs
Datasheet:


background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Function:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Subunit:
Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Contains 8 fibronectin type-III domains.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 tyrosine-protein phosphatase domains.

Database links:

Entrez Gene: 5792 Human

Entrez Gene: 19268 Mouse

Entrez Gene: 72406 Rat

Entrez Gene: 12072 Cow

Omim: 179590 Human

SwissProt: P10586 Human

SwissProt: Q5T021 Human

SwissProt: Q5T022 Human

SwissProt: Q86WS0 Human

SwissProt: A2A8L5 Mouse

SwissProt: Q9EQ17 Mouse

SwissProt: Q6924 Rat

Unigene: 272062 Human

Unigene: 29855 Mouse

Unigene: 2286 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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