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Rabbit Anti-NPY5R/FITC Conjugated antibody
background:
Pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY) are related 36-amino acid hormones. A number of structurally related receptors for these peptides have been isolated, NPY1-R, NPY2-R, NPY3-R, NPY4-R, NPY5-R, and NPY6-R. NPY4-R is expressed in several human tissues, including brain, coronary artery, and ileum. NPY4-R maps to human chromosome 10q11.2. NPY-5R, isolated from rat hypothalamus, encodes a 456-amino acid protein with less than 35% overall identity to known Y-type receptors. The human NPY5-R sequence is nearly identical to, but in the opposite orientation from, that of the human NPY1-R sequence. NPY5-R localizes to the paraventricular hypothalamic nucleus, the lateral hypothalamus, and other locations consistent with a role in the control of feeding behavior. The gene which encodes NPY5-R maps to human chromosome 4q32.2. NPY6-R is abundantly expressed in human heart and skeletal muscle and the gene which encodes NPY6-R maps to human chromosome 5q31.
Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Brain; hypothalamus.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 4889 Human
Entrez Gene: 18168 Mouse
Entrez Gene: 25340 Rat
Omim: 602001 Human
SwissProt: Q15761 Human
SwissProt: O70342 Mouse
SwissProt: Q63634 Rat
Unigene: 519058 Human
Unigene: 598503 Human
Unigene: 10685 Mouse
Unigene: 10532 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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