background:
Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo) (1, 2). Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs (3,4). Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation (5). Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs (6,7).
Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Subunit:
Interacts with ROBO1 and GREM1
Subcellular Location:
Secreted.
Tissue Specificity:
Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.
Similarity:
Contains 1 CTCK (SLCterminal cystine knot-like) domain.
Contains 9 EGF-like domains.
Contains 1 laminin G-like domain.
Contains 20 LRR (leucine-rich) repeats.
Contains 4 LRRCT domains.
Contains 4 LRRNT domains.
Database links:
Entrez Gene: 395293 Chicken
Entrez Gene: 6585 Human
Entrez Gene: 20562 Mouse
Entrez Gene: 65047 Rat
Entrez Gene: 380270 Xenopus laevis
Omim: 603742 Human
SwissProt: O75093 Human
SwissProt: Q80TR4 Mouse
SwissProt: O88279 Rat
Unigene: 66482 Human
Unigene: 40322 Mouse
Unigene: 30002 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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