background:
Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.
Function:
Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthetase proteins suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins.
Subunit:
Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.
Similarity:
Belongs to the UPP synthase family.
Database links:
Entrez Gene: 116150 Human
Entrez Gene: 52014 Mouse
Entrez Gene: 29880 Rat
Omim: 610463 Human
SwissProt: Q96E22 Human
SwissProt: Q99LJ8 Mouse
Unigene: 289008 Human
Unigene: 525826 Human
Unigene: 199964 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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