background:
FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
Function:
FARP2 is a Rho-guanine nucleotide exchange factor that activates RAC1. It plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.
Subunit:
Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 FERM domain.
Contains 2 PH domains.
Database links:
Entrez Gene: 9855 Human
Entrez Gene: 227377 Mouse
SwissProt: O94887 Human
SwissProt: Q91VS8 Mouse
Unigene: 726316 Human
Unigene: 243091 Mouse
Unigene: 28761 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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