background:
The PHF21A gene encodes SHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (SHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Function:
Component of the SHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The SHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the SHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Subunit:
Component of a SHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/SHC80. The SHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in brain. Expressed at much lower level in other tissues.
Similarity:
Contains 1 A.T hook DNA-binding domain.
Contains 1 PHD-type zinc finger.
Database links:
Entrez Gene: 51317 Human
Entrez Gene: 192285 Mouse
Entrez Gene: 362166 Rat
SwissProt: Q96BD5 Human
SwissProt: Q6ZPK0 Mouse
Unigene: 502458 Human
Unigene: 330408 Mouse
Unigene: 450689 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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