background:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.
Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
Subunit:
Binds F-actin. Interacts with ABRA.
Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.
Tissue Specificity:
Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.
Database links:
Entrez Gene: 3983 Human
Entrez Gene: 226251 Mouse
Entrez Gene: 307989 Rat
Omim: 602330 Human
SwissProt: O14639 Human
SwissProt: Q8K4G5 Mouse
Unigene: 438236 Human
Unigene: 538331 Human
Unigene: 593868 Human
Unigene: 217161 Mouse
Unigene: 446592 Mouse
Unigene: 40404 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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