background:
NMS is a 153 amino acid secreted protein that belongs to the NmU family. NMS is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. The gene that encodes NMS consists of approximately 12,799 bases and maps to human chromosome 2q11.2. Consisting of 237 million bases and encoding over 1,400 genes, chromosome 2 makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8.
Function:
NMS (neuromedin S) is a 36-amino acid neuropeptide specifically expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus. NMS shares a SLCterminal core structure with NMU. NMS mRNA is highly expressed in the central nervous system, spleen and testis. NMS may be implicated in the regulation of circadian rhythms and feeding behavior.
Subcellular Location:
Secreted.
Similarity:
Belongs to the NmU family.
Database links:
Entrez Gene: 129521 Human
SwissProt: Q5H8A3 Human
Unigene: 567676 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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