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Rabbit Anti-SLCO1C1/FITC Conjugated antibody
background:
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain.
Function:
SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus
Tissue Specificity:
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain.
Database links:
Entrez Gene: 53647 Cow
Entrez Gene: 53919 Human
Entrez Gene: 51767 Mouse
Entrez Gene: 84511 Rat
Omim: 613389 Human
SwissProt: Q9NYB5 Human
SwissProt: Q9ERB5 Mouse
SwissProt: Q9EPZ7 Rat
Unigene: 47261 Human
Unigene: 284495 Mouse
Unigene: 45744 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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