Rabbit Anti-Neurogranin/FITC Conjugated antibody

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Calmodulin binding protein; Hng; NEUG(55-78); NEUG_HUMAN; Neurogranin (protein kinase C substrate); Ng; NG; NRGN; Protein kinase C substrate; RC3; BICKS.

Cat:

SL11435R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NG/Neurogranin (30-78aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

7.6kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008].

Function:
Acts as a "third messenger" substrate of protein kinase SLCmediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.

Tissue Specificity:
In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.

Post-translational modifications:
Phosphorylated at Ser-36 by PHK

Similarity:
Belongs to the neurogranin family.
Contains 1 collagen-like domain.
Contains 1 IQ domain.

Database links:

Entrez Gene: 616955 Cow

Entrez Gene: 980 Human

Entrez Gene: 12811 Mouse

Entrez Gene: 64356 Rat

Omim: 602350 Human

SwissProt: P35722 Cow

SwissProt: Q92686 Human

SwissProt: P60761 Mouse

SwissProt: Q04940 Rat

Unigene: 524116 Human

Unigene: 335065 Mouse

Unigene: 11236 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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