background:
Sauvagine is a 40-residue peptide isolated and characterized from frog skin. It shares significant structural homology with and elicits similar biological responses as corticotropin-releasing factor (CRF). It has high affinity for both the CRF1 and CRF2 receptors (and low affinity for the CRF binding protein), suggesting its potential as a pharmacological tool for the study of these receptor sub-types. Due to the binding to CRF2 receptors and their role in the release of ACTH and beta-endorphin during stress, possible areas of research with this ligand include anxiety, depression and obesity.
Function:
Hypotensive and diuretic peptide.
Subcellular Location:
Secreted.
Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Database links:
UniProtKB/Swiss-Prot: P01144.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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