Rabbit Anti-ACTHR/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ACTHR/FITC Conjugated antibody

ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; M

Cat:

SL11408R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,)

Immunogen：

KLH conjugated synthetic peptide derived from human MC2 receptor (67-105aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

34kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.

Function:
Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.

Subunit:
Interacts with FALP/MRAP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Melanocytes and corticoadrenal tissue.

DISEASE:
Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:20440]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 48796 Dog

Entrez Gene: 4158 Human

Entrez Gene: 11440 Mouse

Entrez Gene: 282839 Rat

Omim: 607397 Human

SwissProt: Q01718 Human

SwissProt: Q64326 Mouse

Unigene: 248144 Human

Unigene: 426053 Mouse

Unigene: 9292 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall